The Division for Development and Public Relations  

 
YOSEPH  CARACO,  ASSOCIATE PROFESSOR OF PHARMACOLOGY 
Status : ACTIVE Birth place : TEL AVIV
Office Phone: 02-677-6895 Fax: 02-642-3970
E-Mail: caraco@hadassah.org.il
U.R.L:
 
Department Faculty  
INTERNAL MEDICINE FACULTY OF MEDICINE Dept. Description
 
Academic Degree   Institution Year
M.D. HEBREW UNIV. 1983
 
Academic Position   Year
ASSOC. PROFESSOR 2000
SENIOR LECTURER 1996
LECTURER 1991
 
External Academic Positions
Memberships and Fellowships:
Secretary, Isr. Soc. of Clinical Pharmacology
 
Research Interests
Pharmacogenetics. Genetic determinants of drug metabolism and responsive-
ness. G-protein coupled receptors polymorphism - the relevance to
inter-individual variation in pharmacodynamics. Drug metabolism;
interclinic differences in drug disposition and responsiveness.
 
Research Projects
CYP 450 isoenzyes in Israeli sub-populations.
Alleleic polymorphism of beta 2 adrenoceptor in the Israeli
Beta 2 adrenoceptor polymorphism and the bronchdilator effect of
Opioids receptor polymorphism - importance to their analgesic
Evaluation of phenytoin as a putative probe for CYP2C9.
 
Selected Publications
Publication Title   Year
The impact of CYP4F2 genetic polymorphism on warfarin 2012
Mu-opioid receptor (A118G) single-nucleotide polymorphism 2009
Clozapine-induced systemic lupus erythematosus. 2006
Major bleeding caused by warfarin in a genetically susceptible 2002
Phenytoin metabolic ratio: A putative marker of CYP2C9 activity 2001
Impairment of the metabolism of dipyrone in asymptomatic 2001
Zuclopenthixol induced neutropenia and thrombocytopenia. 2000
Hepatocanalicular cholestasis after 24 years of azathioprine 2000
The effect of short-term dipyrone administration on cyclosporine 1999
The impact of ethnic origin and quinidine coadministration on 1999
Comparison of immune reactivity and pharmacokinetics of two 1999
Esophageal perforation after transesophageal echocardiogram. 1999
Simultaneous determination of codeine and its seven metabolites 1998
Cerebrospinal fluid prostaglandins after systemic dipyrone 1998
Cerebrospinal fluid and plasma concentrations of dipyrone 1998
Genetic determinants of drug responsiveness and drug 1998
Ticlopidine induced thrombotic thrombocytopenic purpura. 1998
Drug acetylation in liver disease. 1998
Colchicine biotransformation by human liver microsomes: 1997
Pharmacogenetic determinants of codeine induction by rifampicin: 1997
Impairment of dipyrone's metabolism in asymtomatic carriers of 1997
Digoxin toxicity in a patient with impaired renal function: The 1997
 
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