The Division for Development and Public Relations     ABD-AL-ROOF  HIGAZI,  PROFESSOR OF CLINICAL BIOCHEMISTRY  Status : ACTIVE Birth place : TAMRA (ISRAEL) Office Phone: 02-677-6673 Fax: 02-643-5778 E-Mail: abd@md.huji.ac.il U.R.L:   Department Faculty   CLINICAL BIOCHEMISTRY FACULTY OF MEDICINE Dept. Description   Academic Degree   Institution Year M.D. Univ. of Barcelona 1984 Board cert Israel Medical Assn. 1990   Academic Position   Year PROFESSOR 2008 ASSOC. PROFESSOR 2005 SENIOR LECTURER 1998 LECTURER 1995   Research Interests Allosteric regulation of plasminogen activators by ligands. Involvement of plasminogen activation in the immune response. Regulation of enzyme activities in the fibrinolytic system. Interaction between urokinase and its cellular receptor.   Selected Publications Publication Title   Year The in vitro and in vivo effect of tPA and PAI-1 on blood vessel 2004 Human alpha-defensin regulates smooth muscle cell contraction: A 2002 Binding of urokinase to low density lipoprotein-related receptor 2002 Platelet factor 4 binds to low-density lipoprotein receptors 2002 The structure of lipoprotein(a) and ligand-induced 2001 Plasminogen binding and activation by Mycoplasma fermentans. 2001 Urokinase mediates fibrinolysis in the pulmonary 2000 A region in domain II of the urokinase receptor required for 2000 A peptide derived from the nonreceptor binding region of 2000 The alpha-defensins stimulate proteoglycan-dependent catabolism 2000 Urokinase-derived peptides regulate vascular smooth muscle 2000 Novel interactions between urokinase and its receptor. 2000 Defensin promotes the binding of lipoprotein(a) to vascular 1999 Lysis of plasma clots by urokinase-soluble urokinase receptor 1998 Tissue factor regulates plasminogen binding and activation. 1998 Regulation of single chain urokinase binding, internalization, 1997 Defensin stimulates the binding of lipoprotein (a) to human 1997 Soluble human urokinase receptor is composed of two active 1997 Thermotaxis of human trophoblastic cells. 1996 Interaction of single-chain urokinase with its receptor induces 1996 Defensin modulates tissue-type plasminogen activator and 1996 Single-chain urokinase-type plasminogen activator bound to its 1996 Unesterified long chain fatty acids inhibit the binding of 1996 Enhancement of the enzymatic activity of single-chain urokinase 1995 Inhibition of plasminogen activation by triiodothyronine. 1995 Identification of an inhibitor of tissue-type plasminogen 1995 Inactivation of human anaphylatoxin C5a and C5a des-Arg through 1994 Regulation of neutrophil activation by oleic acid. 1994 Inhibition of plasminogen activation by polymerized ampicillin. 1994 Inhibition of neutrophil activation by fibrinogen. 1994 Regulation of fibrinolysis by free fatty acids. 1994 The effect of ultrasonic irradiation and temperature on 1993 Stimulation of plasmin activity by oleic acid. 1992 Enhanced activity of plasmin and plasminogen activation in the 1992 Inhibition of plasmin by fibrinogen. 1990 Effect of ligands on plasmin kinetics suggests cooperative 1989   © All rights reserved to The Hebrew University of Jerusalem