The Division for Development and Public Relations     ESTHER  SHOHAMI,  DR. LEON DEUTSCH AND DR. MINA DEUTSCH PROFESSOR OF PSYCHOPHA  Status : ACTIVE Birth place : JERUSALEM Office Phone: 02-675-7513 Fax: 02-675-8741 E-Mail: esty@cc.huji.ac.il U.R.L: http://pharmacy.huji.ac.il/eng/staff_win.asp?id=82&type=2   Department Faculty   PHARMACOLOGY - PHARMACY FACULTY OF MEDICINE Dept. Description   Academic Degree   Institution Year Ph.D. HEBREW UNIV. 1973   Academic Position   Year PROFESSOR 2002 ASSOC. PROFESSOR 1997 SENIOR LECTURER 1990 SENIOR RESEARCH FELLOW 1987 LECTURER 1981   Administrative Position   From To Dean of Students 2006   Research Interests Pathophysiology of brain injury - mediators of delayed neuronal damage e.g., prostaglandins, reactive oxygen species, cytokines, cannabinoids, and the cholinergic system in rat and mouse models of injury (closed head injury, CHI). Evaluation of potential therapeutic strategies. CHI as a risk factor for delayed onset of Alzheimer's disease. Genetic manipulations (cytokines or apoE knockouts, acetylcholine-esterase transgenics, and more) as tools for investigating the role of specific mediators in traumatic brain injury. Interrelationship between traumatic brain injury and bone remodeling. Role of endocannabinoids in blood-brain barrier function and in bone remodeling after brain trauma. Mechanisms of neuroprotection induced by pre-conditioning (ischemic or heat acclimation). In vitro model for stretch injury that simulates traumatic conditions in astrocytes.   Research Projects Reactive oxygen species in closed head injury (CHI): The effect of heat acclimation the outcome of CHI: Cytokines and brain injury: Involvement of the cholinergic system in post traumatic events: The effect of Erythropoietin on the outcome of head injury. Cellular and molecular mechanisms of Melatonin and Modulation of the brain redox state and its response to oxidative Bi-directional interaction between neurobehavioral systems and bone. Traumatic brain injury-induced stimulation of systemic bone formation   Selected Publications Publication Title   Year Incensole acetate: A novel neuroprotective agent isolated from 2008 The cannabinoid CB1 receptor regulates bone formation by 2008 Incensole acetate, an incense component, elicits psychoactivity 2008 Incensole acetate, a novel anti-inflammatory compound isolated 2007 Involvement of neuronal cannabinoid receptor, CB1, in regulation 2006 Peripheral cannabinoid receptor, CB2, regulates bone mass. 2006 Heat acclimation increases hypoxia-inducible factor 1alpha and 2005 Erythropoietin is neuroprotective, improves functional recovery, 2005 CB1 cannabinoid receptors are involved in neuroprotection via 2005 Human brain endothelium: Coexpression and function of vanilloid 2004 Brain trauma induces X-box protein 1 processing indicative of 2004 Increase in peripheral benzodiazepine receptors and loss of 2003 The Ras inhibitor S-trans, trans-Farnesylthiosalicylic Acid 2003 Antioxidant properties of the vasoactive endocannabinoid, 2003 Elevated intracranial IL-18 and evidence of neuroprotective 2002 Improved recovery and delayed cytokine induction after closed 2002 Cannabinoids and brain injury: Therapeutic implications. 2002 A cart in search of a horse. 2002 An endogenous cannabinoid (2-AG) is neuroprotective after brain 2001 Regulation of chemokines and chemokine receptors after 2001 N1-acetyl-N2-formyl-5-methoxykynuramine, a biogenic amine and 2001 Closed head injury increases extracellular levels of 2001 Increased hepatic lipid soluble antioxidant capacity as compared 2000 Antisense prevention of neuronal damage following head injury. 2000 Induction of anti-tumor immunity by indomethacin. 2000 Antioxidants attenuate acute toxicity of tumor necrosis 1999 Characterization of pardaxin-induced dopamine release from 1999 Neuroprotective effect of rasagiline, a selective MAO-B 1999 The cognitive and neurochemical effects of the anti-cholinester- 1999 Dexanabinol: A novel neuroprotective drug in experimental focal 1999 Serum-mediated osteogenic effects of head injury on cultured rat 1999 Cerebro-protective effects of ENA 713, a novel 1998 Mechanism of brain protection by nitroxide radicals in 1998 The effects of the acetylcholinesterase inhibitor ENA713 and the 1998 Neuroprotection agonist oxidative stress by serum from heat 1998 Rivastigmine, a brain-selective acetylcholine-sterase inhibitor, 1998 Changes in biological reducing activity in rat brain following 1997 Reduced levels of antioxidants in brain of Apolipoprotein E 1997 Cytokine production in brain following closed head injury: 1997 Diffusion- and T2-weighted MRI of closed head injury in rats: A 1997 Oxidative stress in closed head injury: Brain antioxidant 1997 Europrotective effects of gangliosids on pardaxin-induced 1997 Protection against septic shock and suppression of TNF 1997 Motor and cognitive deficits in Apolipoprotein E-deficient mice 1997 Increased PLA2 is not related to increased GLUT1 expression in 1997 Polyamines induce blood-brain-barrier disruption and edema 1996 An experimental model of closed head injury in mice: 1996 A novel nonpsychotropic cannabinoid, HU-211, in the treatment of 1996 Cerebroprotective effect of stable nitroxide radicals in closed 1996 Inhibition of tumor necosis factor-alpha activity in rat brain 1996 Magnesium given one hour following head trauma decreases brain 1996 Oxygen deprivation and reoxygenation augment prostacyclin 1996 45Ca accumulation in rat brain after closed head injury; 1995 The effect of the adrenocortical axis upon recovery from closed 1995 Long-term effect of HU-211, a novel non-competitive NMDA 1995 High oligomycin concentrations augment 6-keto-PGF1-alpha 1994 Long-term exposure to heat protects against brain damage induced 1994 Closed head injury triggers early production of TNF and IL-6 by 1994 Experimental studies on brain edema after blunt head injury: 1993 A non-psychotropic cannabinoid, HU-211, has cerebroprotective 1993   © All rights reserved to The Hebrew University of Jerusalem