The Division for Development and Public Relations     MICHA E. SPIRA,  DR. G. LEVI DE VEALI PROFESSOR EMERITUS OF NEUROBIOLOGY  Status : EMERITUS Birth place : JERUSALEM Office Phone: 02-658-5091 Fax: 02-563-7033 E-Mail: spira@cc.huji.ac.il U.R.L: http://www.bio.huji.ac.il/eng/staff_in.asp?staff_id=170   Department Faculty   NEUROBIOLOGY FACULTY OF SCIENCE Dept. Description   Academic Degree   Institution Year Ph.D. HEBREW UNIV. 1969   Academic Position   Year EMERITUS 2011 PROFESSOR 1978 ASSOC. PROFESSOR 1976 SENIOR LECTURER 1973 LECTURER 1971   Administrative Position   From To Dean, Faculty of Science 1996 1999 Scientific Director, Interuniversity Inst. for Marine Sci. Eilat 1988 1996 Director, Charles E. Smith Family Laboratory and Prof. Joel 2002 Elkes Laboratory for Collaborative Research in Psychobiology   External Academic Positions Asst. Prof., Assoc. Prof., Albert Einstein College of Medi- cine; Inserm Fellow, Hosp. de La Pitie-Salpetriere, Paris Visiting Prof., Stanford Univ. Royal Soc. Fellow, Cambridge Univ. Founder and director of the Multinational Red Sea research program. Memberships and Fellowships: Isr. Physiological and Pharmacological Soc.; Soc. for Devel- opmental Biology; Amer. Soc. for Cell Biology Soc. for General Physiology   Research Interests Nutritional plasticity, neuronal regeneration and the cell biology of neurodegenerative diseases - a multidisciplinary approach using electrophysiology, digital imaging, confocal microscopy, electron microscopy and molecular biology. Development of neuron-electronic hybrid systems.   Research Projects Cellular and molecular mechanisms underlying growth and synapses Synapse assembly and synaptic plasticity (with Gary J. Bassell,   Selected Publications Publication Title   Year Spine-shaped gold protrusions improve the adherence and 2009 Direct detection of molecular bio-recognition by dipole sensing 2009 Glutamate sensing with enzyme-modified floating-gate field 2009 Reversible transition of extracellular field potential 2008 Formation of microtubule-based traps controls the sorting and 2007 Experimental and theoretical analysis of neuron-transistor 2006 Acetylcholinesterase-ISFET based system for the detection of 2006 On-line confocal imaging of the events leading to structural 2006 Calcium-induced exocytosis from actomyosin-driven, motile 2006 Calcium concentration threshold and translocation kinetics of 2006 Calcium-activated proteases are critical for refilling depleted 2005 Porous silicon substrates for neurons culturing and bio-photonic 2005 Calcium activated proteases are critical for refilling of 2005 Calcium concentration threshold and translocation kinetics of 2005 Depletion type floating gate p-channel MOS transistor for 2004 Neurons culturing and biophotonic sensing using porous silicon. 2004 Electrically conductive 2D-PAN-containing surfaces as a 2004 Effective expression of the green fluorescent fusion proteins in 2003 Critical calpain-dependent ultrastructural alterations underlie 2003 Short window of opportunity for calpain induced growth cone 2002 Calcium, proteases and cytoskeleton remodeling underlie growth 2002 Calcium, protease activation, and cytoskeleton remodeling 2001 High calcium concentrations, calpain activation and cytoskeleton 2000 Partial uncoupling of neurotransmitter release from [Ca2+](i) by 1999 Simultaneous measurement of evoked release and [Ca2+]i(i) in a 1999 Real time imaging of calcium-induced localized proteolytic 1998 Seasonal cycle and population dynamics of the sea hare Aplysia 1998 Induction of growth cone formation by transient and localized 1998 The role of calcium in triggering growth cone formation and 1998 Simultaneous measurement of intracellular Ca2+ and asynchronous 1997 Biochemical Aspects of Marine Pharmacology. 1997 Localized and transient elevations of intracellular Ca2+ induce 1997 Low mobility of the Ca2+ buffers in axons of cultured 1997 Long term survival of isolated axonal segments as revealed by in 1997 Use of Aplysia neurons for the study of cellular 1996 The role of de-novo protein synthesis and exogenous proteins in 1996 Calpain activation is a crucial step in the initiation of growth 1996 Acceleration of membrane recycling by axotomy of cultured 1996 Lifetime energy budget in the sea hare Aplysia oculifera. 1996 Axotomy induces a transient and localized elevation of the free 1995 Alterations of voltage-activated sodium current by a novel 1995 A new family of conotoxins that blocks voltage-gated 1995 Growth and metamorphosis of aplysia-oculifera larvae in 1995 Electrophysiological characterization of a novel conotoxin that 1995 The survival of transected axonal segments of cultured aplysia 1994 Survival of isolated axonal segments in culture: Morphological, 1993 Spatiotemporal distribution of Ca2+ following axotomy and 1993 Resealing of the proximal and distal cut ends of transected 1993 Characterization of the electrophysiological effects of new 1993 Mollusc specific toxins from the venom of conus textile 1991     Patent Name  Year A hybrid device with biological components. 2001 Biosensor for molecules. 2002 Packaging of electronic devices with a small exposed area to the 2003 Electronic device for communication with living cells. 2004   © All rights reserved to The Hebrew University of Jerusalem